In Silico Prediction of Hub Genes Involved in Diabetic Kidney and COVID-19 Related Disease by Differential Gene Expression and Interactome AnalysisArticle Published on 2022-12-192023-07-11 Journal: Genes [Category] COVID19(2023년), [키워드] COVID-19 diabetic kidney disease hub genes in silico analysis metabolic pathways potential therapeutic. [DOI] 10.3390/genes13122412 PMC 바로가기
Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Biochemical Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website [DOI] 10.1007/s10528-022-10206-7 PMC 바로가기
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
Blood transcriptome analysis revealed the crosstalk between COVID-19 and HIVArticle Published on 2022-10-282023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] common differentially expressed genes COVID-19 HIV hub genes small molecular compounds. [DOI] 10.3389/fimmu.2022.1008653 PMC 바로가기
Highly perturbed genes and hub genes associated with type 2 diabetes in different tissues of adult humans: a bioinformatics analytic workflowArticle Published on 2022-10-012022-11-16 Journal: Functional & integrative genomics [Category] meta-analysis, [키워드] analysis Apoptosis applied approach association bioinformatics cell type complex defined diabete diabetes Differential gene expression differentially expressed gene downregulated downstream analysis eligible etiology FIVE Gene Expression Gene Expression Omnibus Genes Genetic greater Highly perturbed genes hub gene hub genes identify insulin Kyoto Manifestations marker gene Meta-analysis metabolomics Microarray non-specific ontologies Pathogenesis pathophysiological pathway Pathways Perturbation profiles provided random effect significantly systematic review T2D tissue Type type 2 diabete type 2 diabetes. upregulated utility [DOI] 10.1007/s10142-022-00881-5 PMC 바로가기
Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach전신 칸디다증에서 기관 특이적 숙주 차등 유전자 발현 분석: 시스템 생물학 접근법Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] 유전자 메커니즘, [키워드] acquisition Activation acute phase response Analysis approach C. albicans can be used Candida Candida albican Candida albicans Candidemia candidiasis Clinical management Co-infection Complication coronavirus disease COVID-19 COVID-19 infections COVID-19 mortality Critical Defense defense mechanisms develop Differential gene expression differentially expressed gene Differentially expressed genes down-regulated drug effector cells event fungal infections hospital Host hub genes human gene human genes Immune cell immune cells immune response immune responses Infection Interaction invasive involved iron kidney leukocyte liver lymphocyte mechanisms molecular mycotic infection mycotic infections occur organ organ-specific organs pathway proliferation protocol recruitment research finding risk Scientific community severe COVID-19 infections sluggish spleen Surveillance systemic Candidiasis Systems biology therapeutic Therapy. yeast [DOI] 10.1016/j.micpath.2022.105677 PMC 바로가기 [Article Type] Article
Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndromeCOVID-19 감염 및 원발성 쇼그렌 증후군에 대한 잠재적인 일반적인 병원성 메커니즘의 생물정보학 분석Article Published on 2022-07-262022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Analysis analysis CDCA2 cellular component cellular components CMPK2 COVID-19 COVID-19 infection cytoHubba database DEGs diagnostic Diagnostic markers differentially expressed differentially expressed gene Differentially expressed genes downloaded Evidence functional annotation Gene Expression Omnibus gene expression profile Gene expression profiles gene regulatory network General population Genes GEO HERC5 hub genes Ifi44 IFI44L IFIT1 IFIT2 IFIT3 marker mechanism metabolic pathway metabolic pathways molecular mechanism molecular mechanisms MX1 participated Pathogenesis pathogenic mechanism pathway Patient performed PPI Prevalence primary Sjogren’s syndrome. progression protein-protein interaction regulatory network reveal RRM2 selected significantly higher Sjögren’s syndrome subsequent analyses syndrome TOP2A transcription factor TYMS [DOI] 10.3389/fimmu.2022.938837 PMC 바로가기 [Article Type] Article
Screening the hub genes and analyzing the mechanisms in discharged COVID-19 patients retesting positive through bioinformatics analysis생물정보학 분석을 통해 퇴원한 코로나19 환자 재검사에서 허브 유전자 스크리닝 및 기전 분석Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] 유전자 메커니즘, [키워드] ALKBH6 AMBRA1 Analysis analyzed ANAPC1 Apoptosis ATP1A1 ATP1A1-AS1 bioinformatics Bioinformatics analysis convalescent COVID-19 COVID-19 patient COVID-19 patients cytoHubba differentially expressed gene discharge discharged DISP1 DOCK4 down-regulated down-regulated gene enrichment analysis expression data FAM149B1 FAM241B Gene Expression Omnibus Gene ontology Genes genomes GEO healthy control hub genes IGLV1-40 immune immune response KEGG Kyoto LRRC69 management mechanism MICAL3 Microarray MIR1249 mRNA Pathogenesis Patient patients PLPPR2 positive PPI PPI network Prognosis prognostic protein-protein interaction PSMG1 R software Rab11b RAB11B-AS1 retesting positive after discharged. Ribonucleic acid risk screened Screening selected significant enrichment SNRPD1 SNRPD2 SORT1 TP53BP1 TRAV18 two group two groups up-regulated virus was performed [DOI] 10.1002/jcla.24495 PMC 바로가기 [Article Type] Article
SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic CatsSARS CoV-2(Delta Variant) 감염 역학 및 국내 고양이의 면역 병인 발생Article Published on 2022-06-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2-expressing cell ACE2-expressing cells acute COVID-19 acute infection animal model animal models B.1.617.2 chemokine chemokine signaling circulating Clinical sign Cluster correlated correlation COVID-19 disease COVID-19 disease course Critical cytokine receptor Delta delta variant develop differentially expressed gene Differentially expressed genes disease Disease progression disease transmission Divergence domestic cats dose downstream dysregulated evaluate feline ferrets flexible genetic modification help highlight Host hub genes identify immunopathology include Infection Infectious virus Inflammatory inflammatory pathways inoculated Interaction interactions intranasally Kinetics lesion lesions limitation lung lung tissue Lungs Mild nasal network analysis non-human primates pathology pathology. pathway peribronchial Pneumocytes Post-infection Prevent progression pulmonary inflammation pulmonary lesion pulmonary lesions Respiratory disease RNA sequencing SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secretion significantly Spread target therapeutic timepoints transgenic mice translational upregulation variant Vascular endothelium Vasculitis Viral antigen Viral protein virus WGCNA wild-type SARS-CoV-2 [DOI] 10.3390/v14061207 PMC 바로가기 [Article Type] Article
Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients간세포암 환자에서 SARS-CoV-2 감염에 대한 표적 및 약물 예측Article Published on 2022-05-312022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis Cell clinician Complication coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical dataset datasets differentially expressed differentially expressed gene drug drugs effective effective drug effective drugs epithelial cell functional genomes HCC HCC patient HCC patients Hepatocellular carcinoma hub genes Human identify Ilomastat infected with SARS-CoV-2 Interaction Kyoto lung epithelial microRNA MicroRNAs miRNA molecular Ontology pandemic pathway Patient patients Protein protein-protein interaction provide Research reveal SARS-CoV-2 SARS-COV-2 infection selected severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 synergistic synergistic effect target terminology therapeutic transcription factor transcriptomic analysis Treatment was performed with COVID-19 [DOI] 10.1371/journal.pone.0269249 PMC 바로가기 [Article Type] Article